Simulations of Redox Mediation within Bioactive Hydrogels of Amperometric Biosensors

Highly hydrated bioactive hydrogels containing immobilized oxidoreductase enzymes and immobilized redox mediators were simulated as the biorecognition layer of amperometric biosensors. The linear dynamic range of the amperometric response of mediated biosensors increases and moves to higher concentration brackets with an increase in the concentration of mediator. This informs the design of biosensors that target the same analyte but possesses several independently addressable electrodes modified with hydrogels that contain different concentrations of mediator. Increases in enzyme concentration increase the linear dynamic range but does not alter the sensitivity of amperometric biosensors. Both sensitivity and linear dynamic range of mediated amperometric enzyme biosensors may be “tuned” by varying the concentrations of the enzyme and the mediator. Simulations effectively guide the initial domains of study of complex systems such as implantable biosensors.     

Correction to: Sub-range Jacobi polynomials

Numerical Algorithms - The first equation in Eq. (2.9) should read     

Uncertainty,economics and optimization: recent developments

Computational Management Science -     

Actinide Organometallic Complexes with π-Ligands

Recent developments and results from the organometallic chemistry of the actinides are reviewed. In the last one and a half years the structural data of about 15 organometallic complexes of transuranium actinides (Np or Pu) have been published, all involving π-ligands in the coordination sphere of the metal ion. On the basis of these data, a comparison of these molecules is presented. Depending on the steric demands of the ligands, effects like the actinide contraction seem to be stronger or weaker in the structural features. This indicates that the interplay between the actinide ion and the π-ligand is rather flexible, enabling the formation of stable bonds over a broad range of actinide ion oxidation states.